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1

Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

Fiume, Luigi, Manerba, Marcella, Vettraino, Marina, Di Stefano, Giuseppina

Journal:

Future Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.31 MB

english, 2014

2

Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment

Stefano, Giuseppina Di, Manerba, Marcella, Ianni, Lorenza Di, Fiume, Luigi

Journal:

Future Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.18 MB

english, 2016

3

Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs

Dr. Antonio Ponzetto, Luigi Fiume, Barbara Forzani, Shi Yun Song, Corrado Busi, Alessandro Mattioli, Cosima Spinelli, Maria Marinelli, Antonina Smedile, Elisabetta Chiaberge, Ferruccio Bonino, Gian Ba

Journal:

Year:

1991

Language:

english

File:

PDF, 752 KB

english, 1991

4

Inhibition of woodchuck hepatitis virus replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route

Prof. Luigi Fiume, Giuseppina Di Stefano, Corrado Busi, Alessandro Mattioli, Maria Rapicetta, Roberto Giuseppetti, Anna Rita Ciccaglione, Claudio Argentini

Journal:

Year:

1995

Language:

english

File:

PDF, 638 KB

english, 1995

5

Synthesis and physicochemical characteristics of a liver-targeted conjugate of fluorodeoxyuridine monophosphate with lactosaminated human albumin

Giuseppina Di Stefano, Michela Tubaro, Marcella Lanza, Carla Boga, Luigi Fiume, Pietro Traldi

Journal:

Rapid Communications in Mass Spectrometry

Year:

2003

Language:

english

File:

PDF, 120 KB

english, 2003

6

Rethinking herpes simplex virus: the way to oncolytic agents

Gabriella Campadelli-Fiume, Carla De Giovanni, Valentina Gatta, Patrizia Nanni, Pier-Luigi Lollini, Laura Menotti

Journal:

Reviews in Medical Virology

Year:

2011

Language:

english

File:

PDF, 371 KB

english, 2011

7

Liver-targeted doxorubicin: effects on rat regenerating hepatocytes

Giuseppina Di Stefano, Massimo Derenzini, Felix Kratz, Marcella Lanza, Luigi Fiume

Journal:

Liver International

Year:

2004

Language:

english

File:

PDF, 344 KB

english, 2004

8

A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

Giuseppina Di Stefano, Luigi Fiume, Michele Baglioni, Luigi Bolondi, Corrado Busi, Pasquale Chieco, Felix Kratz, Francesca Manaresi, Milena Pariali

Journal:

Liver International

Year:

2006

Language:

english

File:

PDF, 149 KB

english, 2006

9

Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors

Giuseppina Di Stefano, Luigi Fiume, Luigi Bolondi, Marcella Lanza, Milena Pariali, Pasquale Chieco

Journal:

Liver International

Year:

2005

Language:

english

File:

PDF, 1.25 MB

english, 2005

10

Activity of albumin conjugates of 5-fluorodeoxyuridine and cytosine arabinoside on poxviruses as a lysosomotropic approach to antiviral chemotherapy

BALBONI, PIER GIORGIO, MINIA, ANNA, GROSSI, MARIA PIA, BARBANTI-BRODANO, GIUSEPPE, MATTIOLI, ALESSANDRO, FIUME, LUIGI

Journal:

Year:

1976

File:

PDF, 302 KB

1976

11

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

Dr. Marcella Manerba, Dr. Marina Vettraino, Prof. Luigi Fiume, Prof. Giuseppina Di Stefano, Dr. Andrea Sartini, Dr. Elisa Giacomini, Dr. Rosa Buonfiglio, Prof. Marinella Roberti, Prof. Maurizio Recana

Journal:

Year:

2012

Language:

english

File:

PDF, 522 KB

english, 2012

12

Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug

Luigi Fiume, Michele Baglioni, Luigi Bolondi, Claudio Farina, Giuseppina Di Stefano

Journal:

Drug Discovery Today

Year:

2008

Language:

english

File:

PDF, 1.62 MB

english, 2008

13

Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells

Luigi Fiume, Marcella Manerba, Marina Vettraino, Giuseppina Di Stefano

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 320 KB

english, 2011

14

A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate

Giuseppina Di Stefano, Marcella Lanza, Felix Kratz, Luca Merina, Luigi Fiume

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 119 KB

english, 2004

15

Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin

Giuseppina Di Stefano, Luigi Fiume, Michele Baglioni, Corrado Busi, Pasquale Chieco, Felix Kratz, Alessandro Mattioli

Journal:

European Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 446 KB

english, 2007

16

Doxorubicin coupled to lactosaminated albumin: Effect of heterogeneity in drug load on conjugate disposition and hepatocellular carcinoma uptake in rats

Giuseppina Di Stefano, Luigi Fiume, Michele Baglioni, Corrado Busi, Luigi Bolondi, Claudio Farina, Filippo Mori, Pasquale Chieco, Milena Pariali, Felix Kratz, Laura Molin, Stefano Salmaso, Paolo Calic

Journal:

European Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 780 KB

english, 2008

17

Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy

Carla Boga, Luigi Fiume, Michele Baglioni, Carlo Bertucci, Claudio Farina, Felix Kratz, Marcella Manerba, Marina Naldi, Giuseppina Di Stefano

Journal:

European Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 883 KB

english, 2009

18

Lactosaminated human albumin, a hepatotropic carrier of drugs

Luigi Fiume, Giuseppina Di Stefano

Journal:

European Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 854 KB

english, 2010

19

Coupling of 5-fluoro 2′-deoxyuridine to lactosaminated poly-l-lysine: an approach to a regional, non-invasive chemotherapy of liver micrometastases

Giuseppina Di Stefano, Corrado Busi, Alessandro Camerino, Massimo Derenzini, Davide Trerè, Luigi Fiume

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 112 KB

english, 2001

20

Inhibition of [3H]thymidine incorporation into DNA of rat regenerating liver by 2′,2′-difluorodeoxycytidine coupled to lactosaminated poly-l-lysine

Giuseppina Di Stefano, Corrado Busi, Alessandro Mattioli, Massimo Derenzini, Davide Trerè, Luigi Fiume

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 289 KB

english, 1999

21

Enhanced liver blood concentrations of adenine arabinoside accomplished by lactosaminated poly-l-lysine coupling: implications for regional chemotherapy of hepatic micrometastases

Giuseppina Di Stefano, Corrado Busi, Alessandro Camerino, Bruno Nardo, Luigi Fiume

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 222 KB

english, 2000

22

Drug targeting in antiviral chemotherapy: A chemically stable conjugate of 9-β-d-arabinofuranosyl-adenine 5'-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells

Luigi Fiume, Bruna Bassi, Corrado Busi, Alessandro Mattioli, Giulia Spinosa

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 662 KB

english, 1986

23

A conjugate of lactosaminated poly-l-lysine with adenine arabinoside monophosphate, administered to mice by intramuscular route, accomplishes a selective delivery of the drug to the liver

Luigi Fiume, Giuseppina Di Stefano, Corrado Busi, Alessandro Mattioli

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 772 KB

english, 1994

24

Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly-l-lysine and administered to mice by intramuscular route

Giuseppina Di Stefano, Corrado Busi, Alessandro Mattioli, Luigi Fiume

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 813 KB

english, 1995

25

Structural and functional insights into IκB-α/HIV-1 Tat interaction

Luigi Vitagliano, Giuseppe Fiume, Pasqualina Liana Scognamiglio, Nunzianna Doti, Rosamaria Cannavò, Antimina Puca, Carlo Pedone, Giuseppe Scala, Ileana Quinto, Daniela Marasco

Journal:

Year:

2011

Language:

english

File:

PDF, 843 KB

english, 2011

26

Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine

Luigi Fiume, Luigi Bolondi, Corrado Busi, Pasquale Chieco, Felix Kratz, Marcella Lanza, Alessandro Mattioli, Giuseppina Di Stefano

Journal:

Journal of Hepatology

Year:

2005

Language:

english

File:

PDF, 289 KB

english, 2005

27

Hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly-l-lysine: Synthesis of the carrier and pharmacological properties of the conjugate

Luigi Fiume, Giuseppina Di Stefano, Corrado Busi, Alessandro Mattioli, Gian Battista Gervasi, Marco Bertini, Carlo Bartoli, Robeta Catalani, Giulio Caccia, Claudio Farina, Adriano Fissi, Osvaldo Piero

Journal:

Journal of Hepatology

Year:

1997

Language:

english

File:

PDF, 843 KB

english, 1997

28

Coupling to lactosaminated poly-L-lysine reduces the toxic effects of ribavirin on red blood cells

Luigi Fiume, Giuseppina Di Stefano, Corrado Busi, Fabio Incitti, Maria Rapicetta, Claudio Farina, Gian Battista Gervasi, Ferruccio Bonino

Journal:

Journal of Hepatology

Year:

1998

Language:

english

File:

PDF, 75 KB

english, 1998

29

Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors

Luigi Fiume, Marina Vettraino, Marcella Manerba, Giuseppina Di Stefano

Journal:

Pharmacological Research

Year:

2011

Language:

english

File:

PDF, 714 KB

english, 2011

30

Ribavirin conjugated with lactosaminated poly-l-lysine: Selective delivery to the liver and increased antiviral activity in mice with viral hepatitis

Giuseppina Di Stefano, Francesco P. Colonna, Alessandro Bongini, Corrado Busi, Alessandro Mattioli, Luigi Fiume

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 874 KB

english, 1997

31

Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells

Fiume, Luigi, Vettraino, Marina, Carnicelli, Domenica, Arfilli, Valentina, Di Stefano, Giuseppina, Brigotti, Maurizio

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 359 KB

english, 2013

32

PENETRATION OF A BETA-AMANITINIRABBIT-ALBUMIN CONJUGATE INTO HEPATIC PARENCHYMAL CELLS

Journal:

Year:

1969

Language:

english

File:

PDF, 393 KB

english, 1969

33

Amatoxins, Phallotoxins, Phallolysin, and Antamanide: The Biologically Active Components of Poisonous Amanita Mushroom

Wieland, Theodor, Faulstich, Heinz, Fiume, Luigi

Journal:

Critical Reviews in Biochemistry and Molecular Biology

Year:

1978

Language:

english

File:

PDF, 5.86 MB

english, 1978

34

Surgical management of acutely presenting gastrointestinal stromal tumors of the stomach among elderly: Experience of an emergency surgery department

Marano, Luigi, Arru, Giovanni Maria Antonio, Piras, Mario, Fiume, Stefania, Gemini, Sergio

Journal:

International Journal of Surgery

Year:

2014

Language:

english

File:

PDF, 199 KB

english, 2014

35

Albumin–drug conjugates in the treatment of hepatic disorders

Fiume, Luigi, Manerba, Marcella, Di Stefano, Giuseppina

Journal:

Expert Opinion on Drug Delivery

Year:

2014

Language:

english

File:

PDF, 920 KB

english, 2014

36

Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes

Manerba, Marcella, Di Ianni, Lorenza, Fiume, Luigi, Roberti, Marinella, Recanatini, Maurizio, Di Stefano, Giuseppina

Journal:

European Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

37

Comment on: Targeting homologous recombination-mediated DNA repair in cancer

Journal:

Expert Opinion on Therapeutic Targets

Year:

2014

Language:

english

File:

PDF, 83 KB

english, 2014

38

Oncolytic herpes virus retargeted to HER-2

Lollini, Pier-Luigi, Menotti, Laura, De Giovanni, Carla, Campadelli-Fiume, Gabriella, Nanni, Patrizia

Journal:

Year:

2009

Language:

english

File:

PDF, 788 KB

english, 2009

39

Impairment of Aerobic Glycolysis by Inhibitors of Lactic Dehydrogenase Hinders the Growth of Human Hepatocellular Carcinoma Cell Lines

Fiume, Luigi, Manerba, Marcella, Vettraino, Marina, Di Stefano, Giuseppina

Journal:

Year:

2010

Language:

english

File:

PDF, 305 KB

english, 2010

40

SPIE Proceedings [SPIE Astronomical Telescopes and Instrumentation - Munich, Germany (Monday 27 March 2000)] Optical and IR Telescope Instrumentation and Detectors - VIMOS mechanical and control system design

Mancini, Dario, LeFevre, Oliver, Caputi, Oreste, Ferragina, Luigi, Fiume Garelli, Valentina, Mancini, Guido, Tommasi Mavar, P., Parrella, C., Perrotta, Francesco, Russo, M., Russo, R., Schibeci, M., S

Year:

2000

Language:

english

File:

PDF, 4.05 MB

english, 2000

41

The Molecular Basis of Herpesviruses as Oncolytic Agents

Menotti, Laura, Campadelli-Fiume, Gabriella, Nanni, Patrizia, Luigi Lollini, Pier, De Giovanni, Carla

Journal:

Current Pharmaceutical Biotechnology

Year:

2012

Language:

english

File:

PDF, 286 KB

english, 2012

42

Laparoscopic Conversion of an Omega in a Roux-en-y Reconstruction After Mini-invasive Total Gastrectomy for Cancer

Rossetti, Gianluca, del Genio, Gianmattia, Maffettone, Vincenzo, Napolitano, Vincenzo, Brusciano, Luigi, Russo, Gianluca, Limongelli, Paolo, Fiume, Irene, Pizza, Francesco, Genio, Alberto del

Journal:

Surgical Laparoscopy Endoscopy & Percutaneous Techniques

Year:

2007

Language:

english

File:

PDF, 195 KB

english, 2007

43

SPIE Proceedings [SPIE Astronomical Telescopes and Instrumentation - Waikoloa, HI (Thursday 22 August 2002)] Large Ground-based Telescopes - VST project: mechanical design optimization

Mancini, Dario, Mancini, Guido, Perrotta, Francesco, Ferragina, Luigi, Fierro, D., Fiume Garelli, Valentina, Pellone, Lorenzo, Caputi, Oreste, Sciarretta, Giovanni, Valentino, Michele, Oschmann, Jacob

Year:

2003

Language:

english

File:

PDF, 1.01 MB

english, 2003

44

Therapy of cytotoxic mushroom intoxication

VESCONI, SERGIO, LANGER, MARTIN, IAPICHINO, GAETANO, COSTANTINO, DOMENICO, BUSI, CARLO, FIUME, LUIGI

Journal:

Critical Care Medicine

Year:

1985

File:

PDF, 393 KB

1985

45

SPIE Proceedings [SPIE Astronomical Telescopes and Instrumentation - Waikoloa, HI (Thursday 22 August 2002)] Large Ground-based Telescopes - VST project: the adapter rotator (M1 cell)

Mancini, Dario, Caputi, Oreste, Cortecchia, Fausto, Ferragina, Luigi, Fierro, D., Fiume, V., Mancini, Guido, Marra, Gabriella, Pellone, Lorenzo, Perrotta, Francesco, Sciarretta, Giovanni, Valentino, M

Year:

2003

Language:

english

File:

PDF, 593 KB

english, 2003

46

The inhibition of lactate dehydrogenase A hinders the transcription of histone 2B gene independently from the block of aerobic glycolysis

Brighenti, Elisa, Carnicelli, Domenica, Brigotti, Maurizio, Fiume, Luigi

Journal:

Biochemical and Biophysical Research Communications

Year:

2017

Language:

english

File:

PDF, 743 KB

english, 2017

47

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

Leoni, Valerio, Vannini, Andrea, Gatta, Valentina, Rambaldi, Julie, Sanapo, Mara, Barboni, Catia, Zaghini, Anna, Nanni, Patrizia, Lollini, Pier-Luigi, Casiraghi, Costanza, Campadelli-Fiume, Gabriella,

Journal:

Year:

2018

Language:

english

File:

PDF, 8.90 MB

english, 2018

48

Light and shadows of a new technique: is photon total-skin irradiation using helical IMRT feasible, less complex and as toxic as the electrons one?

Buglione, Michela, Spiazzi, Luigi, Urpis, Mauro, Baushi, Liliana, Avitabile, Rossella, Pasinetti, Nadia, Borghetti, Paolo, Triggiani, Luca, Pedretti, Sara, Saiani, Federica, Fiume, Alfredo, Greco, Dia

Journal:

Radiation Oncology

Year:

2018

Language:

english

File:

PDF, 2.40 MB

english, 2018

49

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

Avagliano, Angelica, Fiume, Giuseppe, Ruocco, Maria Rosaria, Martucci, Nunzia, Vecchio, Eleonora, Insabato, Luigi, Russo, Daniela, Accurso, Antonello, Masone, Stefania, Montagnani, Stefania, Arcucci,

Journal:

Year:

2020

File:

PDF, 2.16 MB

2020

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